Digital transformation is always accompanied by a multitude of projects to be implemented. In this book, readers are guided through the many facets of systems digitalization. The book begins with an introduction to digital transformation, discussing its importance and impact on the modern world. It then navigates through the crucial stages of system computerization (Chap. 2), database design methodology (Chap. 3), and the strategic choice of programming languages (Chap. 4). Particular emphasis is placed on data security and protection (Chap. 5), a major issue in the current context. The book also presents specific cases of application to different fields, such as healthcare and public and private institutions, highlighting the role of artificial intelligence and intelligent systems (Chap. 6). It closes with a forward-looking vision of the future of digital transformation, offering insights into future trends and innovations.