Information is a valuable asset. As an asset information needs to be secured from cryptanalysis attacks. They are computationally intensive application and consume large amount of CPU time and space at the time of encryption. In this work we have proposed a reliable, an efficient and a more secure system by using our proposed algorithm for encryption and decryption. In cryptography, information should be confidential not only when it is stored in the computer, it should maintain its confidentiality when it is transmitted from one computer to another. For this purpose here we proposed an integrated cryptographic scheme. This scheme is based on a new cryptographic algorithm, message digest algorithm MD5 and RSA Algorithm. Proposed Encryption Algorithm is used to achieve confidentiality, whereas Message Digest Algorithm MD5 is used to verify the integrity of the message and by using the message digest as Encryption key consists of 128 bits is sufficiently long against the cryptographic attacks like Brute-force attack, Dictionary attack to make them impractical. Four major security principles such as Authentication, Confidentiality, Integrity of Data and Non-Repudiation are addressed.