Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis -
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This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CP¿ and CP¿), cyclase-associated p ... Full description
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Description
This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CP¿ and CP¿), cyclase-associated protein (CAP) and coronin 13¿24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
More Information
| Publisher | Springer Nature Singapore |
|---|---|
| Release year | 2020 |
| Cover type | Softcover |
| EAN | 9789811374524 |