Charmer Lewis had the looks of a male model and the smarts of a Harvard student. One would think he would be on top of the world, but that was not the case. Even as a small boy, he was always wondering why he was on this planet and the true meaning of his existence. He excelled in sports, but never enjoyed them. Not really. A home run or a strikeout never affected him like his peers. He was a beautiful man, with many female admirers, but had no real interest in anyone or anything His whole family died in a car crash when he was in his late teens, and, although saddened this happened, he really never had a deep connection with any of them. All of these things started to go round and round his brain until one morning, he got up and decided he had to do something drastic. Hence, he walked out of Harvard and stuck his thumb out at the nearest highway. Not soon after his trip takes him to unchartered territory when an escaped mental patient he encounters at a local diner accidentally shoots and kills the waitress who serves them. Now he not only has an unwanted guest to accompany him, but the fiancé of the now deceased waitress, who just happens to be the local sheriff, in hot pursuit. During this journey he runs into a cast of quirky and unforgettable characters who believe that happiness for them could be found at the 50th anniversary of the Roswell UFO crash or in a pint of Vodka.