Python is one of the most popular programming languages and is used in many different areas. Unlike other languages, it has a grammar familiar to people's language, so it is easy to learn and has low barriers to application. In particular, sympy, a python module introduced in this book, can represent most theories and expressions of mathematics, thus facilitating the acquisition of concepts as well as complex calculations.This book mainly uses the sympy module of python to understand the concepts of differential and integral, and introduces various calculations of differential and integral. Derivatives and integrals are used to implicitly denote the meaning of an expression. In order to understand the implications, it is necessary to understand the calculation process of expressions. In order to understand such a meaning, various methods are used in calculus. This book introduces various techniques of calculus and the various mathematical knowledge used in its calculations using python. This course will help you understand mathematical concepts in this area as well as understand and use the python language.