There are few thousands of rare diseases affecting humans, however, there is often limited professional knowledge, experience and awareness of the manifestations of them and their most appropriate management. This is attributed to the fact that only small number of patients having each one of them. Diagnostic challenges and difficulties, diagnosis delay, and misdiagnoses, inappropriate or unsatisfactory management are commonly associated with rare diseases. The aim of this book is to describe the thirty six case of Cutis Laxa type II (Debre type) in the world, and the second case in Iraq. The second aim is to report the use of a novel therapy in this rare disease which was associated with a beneficial effects.