William had only wanted to develop a method of cloning human tissue. But then, his work was stolen by his best friend, and the very forces of the Devil began perverting his research for the sole purpose of bringing about the end of days. Armed with this knowledge, he decided to destroy Cenetics, the laboratory that stole his creation, along with their malevolent research. As a result, he was confined to a mental hospital, where he learned that this corrupt work was continuing at another facility.

Determined to put an end to Lucifer's plan, William, with the help of his father-in-law, escaped confinement and set off on a quest taking him to distant lands. After several close calls with nefarious demons, William's crusade ultimately failed, along with him suffering intense anguish over the loss of beloved companions.

Now, William must continue pushing forward in an attempt to save the world. Aided by familiar faces, and newfound friends, he encounters hideous creatures, as prophesied events foretelling the end of days intensify. Embracing his destiny, William battles against the very powers of hell, in his final endeavor to save humankind.

In Desolation Salvation, ordinary people meet extraordinary events head-on, in the thrilling conclusion to the Creation Abomination series.