Generalized Quantum Calculus with Applications is devoted to the qualitative theory of general quantum calculus and its applications to general quantum differential equations and inequalities. The book is aimed at upper-level undergraduate students and beginning graduate students in a range of interdisciplinary courses including physical sciences and engineering, from quantum mechanics to differential equations, with pedagogically organized chapters that each concludes with a section of practical problems. Generalized quantum calculus includes a generalization of the q-quantum calculus and the time scale calculus. There are many open problems and difficulties in q-quantum calculus and time-scale calculus, and this book explores how to use the generalized quantum operators to solve difficulties arising in q-quantum calculus and time-scale calculus, including but not limited to generalized quantum integration, generalized quantum chain rules, and generalized quantum Taylor formula. Since generalized quantum calculus includes the q-quantum and time-scale calculus, this book can be utilized by a wide audience of researchers and students. This text is one of few foundational books on generalized quantum calculus and can be used for future discoveries in the area of integral transforms, variational calculus, integral equations, and inequalities in the language of generalized quantum calculus. This book also offers detailed proofs, exercises, and examples to aid instructors, researchers, and users in their studies.