Cloud computing is an emerging technology in which every services are available but still there are some limitations which are restricting its usefulness in e-Health. The aim of this thesis was to explore the limitations and find the opportunities and barriers between cloud computing and e-Health and later purpose it in the form of guidelines. Like any other systems cloud computing adoption also requires prior understanding of human perceptions; human perception can be changed through series of training, workshop and demonstration of system security to the patient, health care personnel and other stakeholders. In the context of this research work, the authors have studied the issues involved in the deployment of cloud computing, associates concerns and factors regarding adoption of cloud computing in e-Health and finally the future of cloud computing in e-Health. In order to identify and to get a deeper understanding of those issues, authors performed literature review, conducted one to one interview with associates both health care personnel and cloud computing) and finally backed up with a web-based survey from the associates for the validation of interview findings.