After his wife's death, former detective Sam Lerner returns to his native New Orleans and ends up at the Gentlemen's Club, an escort establishment owned by his longtime friend. There, he befriends Madsen Cassaise: a young Creole who cares for him as he struggles to overcome his grief and growing dependence on alcohol.

But when Madsen is found dead, Sam is drawn into the investigation. As more escorts disappear, Sam delves ever deeper into the bayous, cemeteries, levees and bistros of the Vieux Carre, and discovers a shocking secret.

In the Big Easy, a place as mysterious as the case itself, the former detective will discover what is truly Inside Sam Lerner.