Matrix isolation is a technique for trapping reactive species at very low temperatures and studying them spectroscopically. This unique introduction to the subject offers detailed practical advice on how to carry out matrix-isolation experiments. Topics discussed include: the strengths and limitations of matrix isolation; how to build a matrix-isolation laboratory from scratch, with full descriptions of all the necessary equipment; ancillary equipment for generating reactive species; various methods for forming low-temperature matrices; and matrix photochemistry with polarized light. The book also includes an extensive collection of classic matrix experiments which have been selected due to their ease of application. This accessible text offers thorough coverage of the topic and will be invaluable to students and researchers in chemistry and related fields.