Adam Hayes pilots a small team to a remote Antarctic research station. Their mission: to investigate the loss of communications. Once there, the group of five find the station deserted, the radio smashed, and several strange piles of empty clothing. Forced to stay the night by a blinding snowstorm, they set out to solve the mystery of the missing crew. Eventually they will learn the horrifying truth-the station is not empty after all, and something unimaginable, dug up from the deep ice, roams the complex. Now they must fight for their lives against a cunning, thinking monster-and those who would unleash this terror on the rest of the world.

Dr. Edward Hamline runs a clinic for terminally ill orphans. Over many years he has secretly experimented on the children using materials retrieved from Antarctica. He hopes to exploit the astounding healing properties while eliminating the fatal side effects. Unfortunately, without the correct DNA match, he has achieved only minimal results, which always turns to failure. He arranges to have Brandon Dahl, a boy whose past may lead to success, moved to his clinic. But others know of Dr. Hamline's evil experiments and want to stop him and save Brandon and the other children. All the while, a monster is on the loose.