Nefertiti's Sister takes place in a historically accurate ancient Egypt of the 18th Dynasty in the New Kingdom-the time of Nefertiti and her husband, King Akhenaten, as well as ultimately by the famous "boy king" Tut.

The story centers around a clutch of royal women who are doing everything they can to keep each other safe and supported in a dominantly patriarchal culture, particularly in the areas of sex, politics, love, and birth. Out of necessity, a life-saving scheme is hatched that not only plunges the women involved into a conspiracy far over their heads but also leaves their mark forever on history.