Four Middle Eastern terrorists led by Ahmed Musa Mohammed infect themselves with the smallpox virus from a dying child they find with the natural disease in rural Somalia and travel to the United States to deliberately spread the infection among the crowds of Christmas shoppers in four American cities. Dr. Harry Bennett, a physician practicing near Chicago, sees the first two cases of smallpox, a mother and daughter, and he watches helplessly as they become seriously ill and die. A few days later, Dr. Vicky Anderson, an emergency room physician in New York City, diagnoses the third case. The outbreak is recognized as a terrorist attack, but even with a massive public health response, smallpox explodes across America, engulfing the country in fear and panic. Many Americans believe that the threat of a biological terrorist attack is genuine, and Pox describes a disturbingly real possibility. In Pox, the reader witnesses the destructiveness of self-righteous, intolerant fanatics who devise a grim plan to wreak pain and havoc on America. Pox offers an intense look at how contradictory ideologies and philosophies realistically play out, and causes us to realize our vulnerabilities.