Disc jockey Edgar Allan Twain has some crazy ideas. He believes he can restore justice, liberty and the pursuit of happiness to a world ruled by corruption, prohibition and greed. This crusade destroys his radio career in the U.S. and leaves him scraping by at a tiny border station in Juárez, where he discovers that criticizing the drug cartels can cost him more than a job. He runs for his life, taking his one-legged girlfriend Juanita with him to Squirrel Bay, the marijuana-growing capital of Northern California. Here, Edgar finally gets a DJ job that fits his principles and quickly earns a devoted fan-base. By the time their Juárez enemies track them down, Edgar and Juanita have surrounded themselves with a bizarre assemblage of allies: modern-day wizards, an ancient extraterrestrial, a Cossack she-warrior, and a mad scientist determined to destroy his own freakish creations. Once they harness the power of some unique quantum inventions and the imagery of the death cult Santa Muerte, this crew of misfits gets a fighting chance against the bloodthirsty cartels. The bodies - and the laughs - pile up quickly as Edgar and his friends wage a war for justice and freedom...and for their lives.