Structure-Based Drug Discovery -
-20% with code BOOKS
Shipping in 12-18 days
30-day return policy
The last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential. Taken together, the numerous recent advances have made it possible to tackle difficult biological targets with a high probability of success: intact bacterial ribosomes have been structurally elucidated, as well as eukaryotic trans-membrane proteins ... Full description
You May Also Like
TOP
The Myth of Normal: Trauma, Illness, and Healing in a Toxic Culture
-20% with code BOOKS
In stock at our supplier
TOP
The Checklist Manifesto: How to Get Things Right
-20% with code BOOKS
In stock at our supplier
TOP
No Bad Parts: Healing Trauma and Restoring Wholeness with the Internal Family Systems Model
-20% with code BOOKS
In stock at our supplier
TOP
On Connection: 'Powerful' MATT HAIG
-20% with code BOOKS
In stock at our supplier
TOP
Oxford Handbook of Clinical Medicine
Peter Hateley, Iain McGurgan, Ian B. Wilkinson, Tim Raine, Dearbhla Kelly, Kate Wiles
-20% with code BOOKS
In stock at our supplier
TOP
Harrison's Principles of Internal Medicine (Vol.1 & Vol.2)
Stephen Hauser, Joseph Loscalzo, Steven Holland, Dan Longo, J. Larry Jameson, Dennis Kasper, Carol Langford, Anthony Fauci
-20% with code BOOKS
In stock at our supplier
TOP
The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma
-20% with code BOOKS
In stock at our supplier
TOP
Oxford Handbook of Anaesthesia
-20% with code BOOKS
In stock at our supplier
TOP
Maybe You Should Talk to Someone: a therapist, her thearapist, and our lives revealed
-20% with code BOOKS
In stock at our supplier
TOP
How Not To Die: Discover the foods scientifically proven to prevent and reverse disease
-20% with code BOOKS
In stock at our supplier
TOP
Lifespan: Why We Age - and Why We Don't Have To
-20% with code BOOKS
In stock at our supplier
TOP
Vademecum Metabolicum: Diagnosis and Treatment of Inborn Errors of Metabolism Forword by William L. Nyhan, San Diego, USA
Johannes Zschocke, Georg F. Hoffmann
-20% with code BOOKS
In stock at our supplier
TOP
Hamric & Hanson's Advanced Practice Nursing: An Integrative Approach
Eileen T. O'Grady, Susanne J. Phillips, Mary Fran Tracy
-20% with code BOOKS
In stock at our supplier
TOP
Cellular and Molecular Immunology
Sarah Henrickson, Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai
-20% with code BOOKS
In stock at our supplier
TOP
Physics, Pharmacology and Physiology for Anaesthetists: Key Concepts for the FRCA
Matthew E. Cross, Emma V. E. Plunkett
-20% with code BOOKS
In stock at our supplier
TOP
Pocket Guide to Teaching for Clinical Instructors
-20% with code BOOKS
In stock at our supplier
TOP
Oxford Handbook of Critical Care
Andrew Webb, Mervyn Singer, Alice Carter
-20% with code BOOKS
In stock at our supplier
TOP
The Wills Eye Manual: Print + eBook with Multimedia: Office and Emergency Room Diagnosis and Treatment of Eye Disease
-20% with code BOOKS
In stock at our supplier
TOP
Who Deserves Your Love: How to Create Boundaries to Start, Strengthen or End Any Relationship
-20% with code BOOKS
In stock at our supplier
Description
The last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential. Taken together, the numerous recent advances have made it possible to tackle difficult biological targets with a high probability of success: intact bacterial ribosomes have been structurally elucidated, as well as eukaryotic trans-membrane proteins like the potassium channel and GPCRs. It is now possible for medicinal chemists to have access to structural information on their latest small molecule candidates bound to the therapeutic target within days of compound synthesis, allowing structure guided ligand optimization to occur in "real time". Structure-Based Drug Discovery presents an array of methods used to generate crystal structures of biological macromolecules, how to leverage the structural information to design novel ligands anew, and how to iteratively optimize hits and convert them to leads. Written in the successful Methods in Molecular Biology¿ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.  Authoritative and easily accessible, Structure-Based Drug Discovery aims to provide scientists interested in adding SBDD to their arsenal of drug discovery methods with well-honed, up-to-date methodologies.
More Information
| Publisher | Humana Press |
|---|---|
| Series | Methods in Molecular Biology |
| Release year | 2016 |
| Cover type | Softcover |
| EAN | 9781493961375 |