George Leon is a hip, hardworking magazine publisher and quite the ladies man, too. On a pretty March morning, he is driving merrily down Interstate 75 in South Florida, when a fuel tanker blows up right in front of him. Almost killed in the ensuing fire and chaos, he wants to know why, exactly, the truck erupted. An investigative journalist at heart, he soon discovers the explosion was no accident but rather part of an elaborate plot, targeting tankers along the same stretch of highway. In concert with a rookie reporter on his staff, and while courting a beautiful Latina barmaid, George closes in on a very dangerous culprit, only to end up taking a harrowing death ride - in a tanker on I-75.