The purpose of this guidance document is for the appropriate selection, procurement, utilization, and maintenance of oxygen concentrators. This document also focuses on recommendations for the appropriate use and maintenance of oxygen concentrators in an effort to increase the availability, management, and quality of oxygen concentrators and, ultimately, to improve health outcomes in LRS. This document is intended to serve as a resource for the planning and provision of local and national oxygen concentrator systems for use by administrators, clinicians, and technicians who are interested in improving access to oxygen therapy and reducing global mortality associated with hypoxaemia.