Deep in the jungle of Peru, a black, skittering mass devours an American tourist party whole. FBI agent Mike Rich investigates a fatal plane crash in Minneapolis and makes a gruesome discovery. Unusual seismic patterns register in a Indian earthquake lab, confounding the scientists there. The Chinese government "accidentally" drops a nuclear bomb in an isolated region of its own country. The first female president of the United States is summoned to an emergency briefing. And all of these events are connected.

As panic begins to sweep the globe, a mysterious package from South America arrives at Melanie Guyer's Washington laboratory. The unusual egg inside begins to crack. Something is spreading...
The world is on the brink of an apocalyptic disaster. An virulent ancient species, long dormant, is now very much awake. But this is only the beginning of our end...