The Second Coming? carries readers to a world not unlike the one we already live in, where religious intolerance, misunderstanding, and misguided political ambition have divided humankind into hostile factions. The East and West are pitted against each other, on the brink of a holy war between Islam and Christianity-and one man has decided to take preemptive action.

Bobby Joe Sabbath, a leading American televangelist, wants nothing more than to awaken his fellow Christians to the impending holy war and to be seen as nothing less than a hero in his followers' eyes. To accomplish these ends, Sabbath sets out to unseat the US president and replace him with the more conservative vice president, Mary Stokes. But getting Stokes into office proves impossible after she is ambushed, injured, and irrevocably altered by a mysterious new drug called REGEN.

The drug reformats Stokes's brain and leaves her unable to verbally communicate-though, for all it takes from her, REGEN gives something back. Stokes is unexpectedly, unexplainably pregnant, and Sabbath is determined to use her baby as a prop to announce Christ's second coming. But as determined as Sabbath is, others are determined to stop him.